Comparison Insight Bone Measurements by Histomorphometry and μCT

Histomorphometry of bone.

This review of the histomorphometry of bone outlines methods of biopsy and processing of specimens in the laboratory, the basic principles of morphometry, and the measurements made in order to obtain estimates of the proportional volumes and surfaces occupied by different components of bone. Variability such as that between methods, observers and laboratories is discussed and a brief outline of...

Comparison of two bone trephine instruments used for quantitative histomorphometry.

Transilial bone samples were obtained at necropsy using trephine instruments with internal diameters of 2 mm and 7 mm. Undecalcified histological sections were prepared and two structural histomorphometric variables (percentage of trabecular bone volume and surface density of bone) were estimated by a Quantimet 720 image analyser. The differences between the variables measured from the two adja...

Issues in modern bone histomorphometry.

This review reports on proceedings of a bone histomorphometry session conducted at the Fortieth International IBMS Sun Valley Skeletal Tissue Biology Workshop held on August 1, 2010. The session was prompted by recent technical problems encountered in conducting histomorphometry on bone biopsies from humans and animals treated with anti-remodeling agents such as bisphosphonates and RANKL antibo...

A Novel Image Transformation Scheme Minimizes Interpolation Artifact and Allows Reproducible Measurement of Trabecular Bone Remodeling through μCT-Based In Vivo Dynamic Bone Histomorphometry

Micro-CT in the Assessment of Pediatric Renal Osteodystrophy by Bone Histomorphometry.

BACKGROUND AND OBJECTIVES Computed tomography (CT) measurements can distinguish between cortical and trabecular bone density in vivo. High-resolution CTs assess both bone volume and density in the same compartment, thus potentially yielding information regarding bone mineralization as well. The relationship between bone histomorphometric parameters of skeletal mineralization and bone density fr...